A film featuring the character was in development at Universal Pictures, 20th Century Fox, and New Line Cinema at various times since 1990, before Marvel Studios reacquired the rights in 2005. Marvel put the project in production as its first self-financed film, with Paramount Pictures distributing. Favreau signed on as director in April 2006, and faced opposition from Marvel when trying to cast Downey in the title role; the actor was signed in September. Filming took place from March to June 2007, primarily in California to differentiate the film from numerous other superhero stories that are set in New York City-esque environments. During filming, the actors were free to create their own dialogue because pre-production was focused on the story and action. Rubber and metal versions of the armor, created by Stan Winston's company, were mixed with computer-generated imagery to create the title character.
When I caught up with "Iron Man," a broken hip had delayed me and the movie had already been playing for three weeks. What I heard during that time was that a lot of people loved it, that they were surprised to love it so much, and that Robert Downey Jr.'s performance was special. Apart from that, all I knew was that the movie was about a big iron man. I didn't even know that a human occupied it, and halfway thought that the Downey character's brain had been transplanted into a robot, or a fate equally weird.
The solution to such dilemmas is that the armored suits look the way they do for entirely cinematic reasons. The bad iron man should look like a mean machine. The good iron man should utilize the racing colors of Tony Stark's favorite sports cars. It wouldn't be nearly as much fun to see a fight scene between two refrigerators crossed with the leftovers from a boiler room.
IRON MAN (IMA) peptides, a family of small peptides, control iron (Fe) transport in plants, but their roles in Fe signaling remain unclear. BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Here, we show that IMA peptides interact with BTS. The C-terminal parts of IMA peptides contain a conserved BTS interaction domain (BID) that is responsible for their interaction with the C terminus of BTS. Arabidopsis thaliana plants constitutively expressing IMA genes phenocopy the bts-2 mutant. Moreover, IMA peptides are ubiquitinated and degraded by BTS. bHLH105 and bHLH115 also share a BID, which accounts for their interaction with BTS. IMA peptides compete with bHLH105/bHLH115 for interaction with BTS, thereby inhibiting the degradation of these transcription factors by BTS. Genetic analyses suggest that bHLH105/bHLH115 and IMA3 have additive roles and function downstream of BTS. Moreover, the transcription of both BTS and IMA3 is activated directly by bHLH105 and bHLH115 under Fe-deficient conditions. Our findings provide a conceptual framework for understanding the regulation of Fe homeostasis: IMA peptides protect bHLH105/bHLH115 from degradation by sequestering BTS, thereby activating the Fe deficiency response.
Phil Kessel is set to play in his 990th consecutive game Tuesday night (10:30 p.m. ET, ESPN), meaning the Vegas Golden Knights winger will pass retired defenseman Keith Yandle to become the NHL's all-time iron man.
In an effort to better understand "Phil the Thrill" and how he became the NHL's iron man, we spoke with individuals connected to all five of his stops on the NHL: with the Boston Bruins (2006-09), Toronto Maple Leafs (2009-2015), Pittsburgh Penguins (2015-19, winning back-to-back Stanley Cups), Arizona Coyotes (2019-22) and the Golden Knights this season.
If you had told me when I first met Phil that he would set the NHL's iron man record, I would have called you absolutely crazy. I would have said you are out of your mind. I would have taken whatever odds were on it at the time.
When Tony gives his Apogee Award to a costumed Roman soldier at the Caesar's Palace casino, he paraphrases a quote by Jesus Christ from Mark 12:17: "Unto them, render to Caesar the things that are Caesar's, and to God the things that are God's." It's ironic, given that at the time he makes this allusion, Tony is primarily motivated by wealth and ambition. He also has an inflated self-image of himself as a savior of sorts, whose weapons prevent the world from descending into chaos. 781b155fdc